Newborn screening for sickle cell disease: necessary but not sufficient
نویسندگان
چکیده
منابع مشابه
Newborn screening for sickle cell disease: necessary but not sufficient.
ickle cell disease is a global health problem that ffects > 300,000 newborns per year, predominantly in Subaharan Africa,1 where mortality is estimated to be > 50% y age 5 years for those with homozygous hemoglobin S HbSS).1 In Brazil, there are estimated to be > 30,000 indiiduals with sickle cell disease and 2,500 newborns per ear, making this the most common genetic disorder in the ountry.2 A...
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the risk of sickle cell complications that is a common hemoglobin disorder in Southwest Iran. This study aimed at determining the incidence of Sickle Cell Disease (SCD) and other Hemoglobinopathies in newborn being at risk based on ethnic origin. Materials and Methods: In this descriptive epidemiologic study, between September 2013 and September 2015, 8363 newborn blood samples were test...
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BACKGROUND Neonatal screening programs for sickle cell disease are now widespread in North American and European countries. Most programs apply isoelectric focusing or HPLC to detect hemoglobin variants. Because tandem mass spectrometry (MS/MS) is being used for screening of inherited metabolic disorders and allows protein identification, it was worth testing for hemoglobinopathy screening. M...
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Newborn screening is now integrated into routine neonatal practice in many parts of the world, and the overall ethical acceptability of newborn screening programmes is well recognised.1 Although the procedure corresponds in essence to genetic screening, it is seldom referred to as such and is often categorised as a public health disease prevention programme aimed at early detection and treatmen...
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ژورنال
عنوان ژورنال: Jornal de Pediatria (Versão em Português)
سال: 2015
ISSN: 2255-5536
DOI: 10.1016/j.jpedp.2015.03.014